Difference Between Tobacco and Nicotine
The main difference between Tobacco and Nicotine is that tobacco is a plant product containing thousands of chemicals, while nicotine is just one specific chemical compound. Tobacco is a dried leaf mixture used in cigarettes and cigars, while Nicotine is the addictive stimulant naturally found in tobacco leaves.
Key takeaways
- Tobacco is a plant — nicotine is the addictive chemical compound naturally found inside its leaves.
- Nicotine drives addiction — tobacco delivers it through smoke, but nicotine also exists in gums and patches.
- Tobacco brings extra harm — burning it produces tar and carcinogens, while pure nicotine carries fewer toxins.
- Nicotine suits replacement therapy — tobacco products serve recreational use, but cessation aids use isolated nicotine only.
- Common mistake is conflating — banning tobacco does not ban nicotine, which remains legal in many alternatives.
Table of Contents18 sections
Difference Between Tobacco and Nicotine: Comparison Table
| Aspect | Tobacco | Nicotine |
|---|---|---|
| Definition | A leafy plant, primarily Nicotiana tabacum, cultivated for curing and smoking. | A nitrogen-containing alkaloid chemical compound found naturally in tobacco leaves. |
| Purpose | Used to create consumer products like cigarettes, cigars, and chewing tobacco. | Serves as the primary psychoactive agent that drives addiction in tobacco users. |
| Core Mechanism | Burning leaves releases smoke containing thousands of chemicals, including tar and carbon monoxide. | Binds to nicotinic acetylcholine receptors in the brain, triggering dopamine release. |
| Physical State | Exists as dried, cured plant matter, typically brown or greenish in color. | Appears as a colorless to pale yellow oily liquid in its pure form. |
| Chemical Composition | Contains over 7,000 chemicals, including nicotine, nitrosamines, and heavy metals. | Composed of carbon, hydrogen, nitrogen, and oxygen atoms in a single molecule. |
| Addictive Agent | Acts as the delivery vehicle that carries nicotine into the body through inhalation. | Is the specific substance responsible for physical dependence and addiction. |
| Harm Profile | Burning and inhaling causes lung cancer, COPD, and cardiovascular disease. | Alone, poses lower risk but still raises heart rate and blood pressure. |
| Cancer Link | Combustion produces carcinogens like benzene and formaldehyde that damage DNA. | Not classified as a direct carcinogen by major health agencies. |
| Delivery Method | Consumed via smoking, chewing, or snuffing the processed plant material. | Delivered through patches, gum, lozenges, sprays, or vaporized e-liquids. |
| Regulatory Status | Subject to strict FDA regulations on sale, advertising, and age restrictions. | Regulated as a drug when in therapeutic products like nicotine replacement therapy. |
| Onset Speed | Inhaled smoke reaches the brain in approximately 10 to 20 seconds. | Transdermal patches deliver slowly over hours, while inhalers act within minutes. |
| Dosage Control | Users cannot measure exact nicotine intake due to varying leaf potency. | Products offer precise milligram doses, from 2 mg gum to 21 mg patches. |
| Purity Level | Contains thousands of additives and contaminants from soil and processing. | Extracted and purified to high concentrations for pharmaceutical-grade use. |
| Half-Life | Plant material itself has no metabolic half-life in the human body. | Nicotine has a plasma half-life of roughly two hours in most adults. |
| Metabolism | Plant compounds are processed by the liver into various byproducts. | Broken down primarily by the liver enzyme CYP2A6 into cotinine. |
| Withdrawal Effects | Quitting tobacco triggers cravings for the entire smoked product ritual. | Nicotine cessation causes irritability, anxiety, and concentration difficulties. |
| Tolerance Build | Users develop tolerance to the sensory and behavioral aspects of smoking. | Repeated exposure leads to upregulation of receptors and higher intake needs. |
| Cost Factor | Cigarette packs cost roughly $6 to $15 depending on state taxes. | Nicotine gum costs about $0.50 to $1.00 per piece at retail. |
| Lethal Dose | Consuming raw leaves can cause poisoning but rarely proves fatal. | Approximately 30 to 60 mg of pure nicotine can be lethal for adults. |
| Environmental Impact | Cultivation requires large water use and curing emits significant air pollutants. | Manufacturing is small-scale but e-liquid waste adds plastic and chemical litter. |
| Social Perception | Smoking is increasingly stigmatized and banned in most public indoor spaces. | Nicotine replacement therapy is viewed as a medical aid for quitting. |
| Legal Age | Purchase age is 21 years in the United States and most global markets. | Nicotine products also require buyers to be at least 21 years old. |
| Flavor Profile | Offers earthy, smoky, or sweet notes depending on curing and blending. | Pure nicotine has a sharp, peppery, and burning taste on the tongue. |
| Storage Needs | Must be kept dry and sealed to prevent mold and moisture damage. | Requires airtight, light-resistant containers to prevent oxidation and degradation. |
| Market Forms | Sold as cigarettes, cigars, pipe tobacco, snuff, and rolling leaf. | Marketed as gums, patches, lozenges, nasal sprays, and vape juice. |
| Primary Users | Adult smokers and smokeless tobacco consumers seeking ritual or habit. | Smokers attempting cessation plus some recreational vape users. |
| Dependency Risk | Combines nicotine addiction with behavioral cues like hand-to-mouth motion. | Creates chemical dependency but lacks the reinforcing smoke rituals. |
| Secondhand Impact | Side-stream smoke exposes bystanders to toxic particulates and gases. | Vapor from e-cigarettes contains fewer toxins but still emits fine particles. |
| Key Limitation | Cannot be separated from carcinogenic byproducts when combusted. | Does not address the behavioral or social aspects of smoking addiction. |
| Best-Fit Scenario | Choose for traditional cultural ceremonies or if avoiding processed chemicals. | Choose for medically supervised cessation or harm reduction therapy. |
What Is Tobacco?
Tobacco is a plant grown for its leaves, which are dried and processed for smoking, chewing, or sniffing. It contains nicotine, the chemical that makes use addictive. Tobacco exists primarily for recreational use, though it also appears in some traditional medicines.
Definition of Tobacco
Tobacco refers to cured leaves of plants in the Nicotiana genus, chiefly Nicotiana tabacum. These leaves contain nicotine and other alkaloids. The plant is cultivated commercially worldwide, then manufactured into products like cigarettes, cigars, pipe tobacco, and smokeless forms for human consumption.
Key Characteristics of Tobacco
| Characteristic | What It Means in Practice |
|---|---|
| Nicotine content | Delivers the addictive stimulant that drives repeated use and dependency. |
| Drying process | Leaves are cured through air, fire, or flue methods to change flavour and potency. |
| Combustible form | Burning releases tar and carbon monoxide alongside nicotine when smoked. |
| Smokeless form | Chewed or snuffed products deliver nicotine without inhaling smoke. |
| Addictive nature | Regular use quickly creates physical and psychological dependence in most users. |
| Flavour profile | Natural taste ranges from sweet and earthy to sharp, depending on strain and curing. |
| Legal regulation | Sale is restricted by age, taxation, and advertising bans in most countries. |
| Plant origin | Grown in warm climates like the Americas, Africa, and parts of Asia. |
| Chemical complexity | Contains thousands of compounds, many toxic or carcinogenic when burned. |
| Cultural history | Used ceremonially by Indigenous peoples long before global commercial trade began. |
Common Examples of Tobacco
- Cigarettes – the most widely sold form, with finely cut leaves rolled in paper for smoking.
- Cigars – whole or chopped leaves wrapped in a tobacco leaf, smoked without inhaling deeply.
- Pipe tobacco – loose, often flavoured leaves packed into a bowl and smoked slowly.
- Chewing tobacco – loose leaf or plug placed between cheek and gum to release nicotine.
- Snuff – finely ground dry tobacco inhaled through the nose or placed in the mouth.
- Hookah tobacco – moist, sweetened leaves heated with charcoal and smoked through water.
- Bidis – thin, hand-rolled cigarettes from India with unprocessed tobacco in a tendu leaf.
- Kreteks – Indonesian cigarettes blending tobacco with cloves for a distinct flavour.
- Loose-leaf tobacco – bulk dried leaves sold for hand-rolling your own cigarettes.
- Snus – moist, pasteurised tobacco pouches placed under the upper lip, popular in Sweden.
Advantages and Limitations of Tobacco
| Advantages | Limitations |
|---|---|
| Provides a temporary calming effect that users report for stress relief. | Smoking causes lung cancer, COPD, and heart disease in a large share of long-term users. |
| Offers a reliable stimulant boost that sharpens focus for short periods. | Nicotine addiction is extremely hard to break; most quit attempts fail without help. |
| Supports agricultural economies in developing regions like Zimbabwe and Malawi. | Secondhand smoke harms bystanders, including children, with no safe exposure level. |
| Has deep cultural and ceremonial roots in some Indigenous traditions. | Regular use stains teeth, damages gums, and causes premature tooth loss. |
| Can be used as a natural pesticide in some traditional farming practices. | Smokeless forms still cause oral, oesophageal, and pancreatic cancers. |
| Provides a social ritual that some users find enjoyable in group settings. | High taxation makes it a costly habit; a pack-a-day smoker spends thousands yearly. |
| Creates jobs in farming, manufacturing, and retail sectors globally. | Burning releases tar that coats airways, leading to chronic bronchitis and emphysema. |
| Has a long shelf life when stored dry, making it easy to stockpile. | Impotence and reduced fertility are documented consequences of heavy tobacco use. |
| Offers a familiar, predictable dose of nicotine for those managing withdrawal. | Litter from cigarette butts is a major environmental pollutant, contaminating soil and water. |
| Can be grown locally by smallholders for personal or regional sale. | No form of tobacco is safe; even low-tar or organic varieties carry serious health risks. |
What Is Nicotine?
Nicotine is a stimulant alkaloid naturally produced in tobacco leaves as a defense against insects. It binds to receptors in the brain, releasing dopamine and creating alertness and pleasure. These effects make it the primary addictive compound in tobacco products.
Definition of Nicotine
Nicotine is a nitrogen-containing organic compound (C10H14N2) that acts as a parasympathomimetic stimulant. It binds to nicotinic acetylcholine receptors in the central and peripheral nervous systems, triggering neurotransmitter release. In pure form, it is a colorless, oily liquid with a bitter taste.
Key Characteristics of Nicotine
| Characteristic | What It Means in Practice |
|---|---|
| High addictiveness | Reinforces repeated use by rapidly delivering dopamine to the brain's reward pathways. |
| Rapid absorption | Reaches the brain within 10 seconds of inhalation, producing an immediate effect. |
| Stimulant effect | Increases heart rate, blood pressure and alertness, similar to caffeine but stronger. |
| Short half-life | Levels drop by half in about 2 hours, driving frequent redosing to maintain effects. |
| Natural pesticide | Acts as a neurotoxin against insects, which is why plants produce it. |
| Receptor specificity | Binds precisely to nicotinic acetylcholine receptors, not other receptor types. |
| Dose-dependent toxicity | Small amounts stimulate, but higher doses cause nausea, vomiting and respiratory failure. |
| Crosses blood-brain barrier | Enters brain tissue quickly, altering mood, cognition and attention. |
| Metabolized by liver | Broken down into cotinine, which stays in the body for days and is testable. |
| Temperature volatility | Vaporizes around 247°C, allowing inhalation without burning the plant material. |
Common Examples of Nicotine
- Cigarettes – the most common delivery system, combusting tobacco to release nicotine into inhaled smoke.
- Chewing tobacco – loose leaves held in the mouth, releasing nicotine through direct mucosal absorption.
- Nicotine patches – transdermal systems delivering a steady dose through skin over 16 to 24 hours.
- Nicotine gum – a chewing resin that releases nicotine into saliva for buccal absorption.
- E-cigarettes – battery-powered devices that vaporize nicotine-containing e-liquid for inhalation.
- Nicotine lozenges – dissolving tablets that slowly release nicotine for oral absorption.
- Snus – moist, pasteurized tobacco pouches placed under the upper lip for nicotine uptake.
- Nicotine nasal spray – a prescription product delivering nicotine through the nasal lining for rapid relief.
- Nicotine inhalers – plastic devices delivering nicotine vapor through the mouth, mimicking hand-to-mouth habits.
- Pipe tobacco – loose-cut leaves smoked in a pipe, providing nicotine through inhaled or oral smoke.
Advantages and Limitations of Nicotine
| Advantages | Limitations |
|---|---|
| Improves short-term focus and concentration in some users. | Highly addictive, with withdrawal symptoms like irritability and cravings. |
| Provides temporary relief from stress and anxiety. | Raises heart rate and blood pressure, straining the cardiovascular system. |
| Used in FDA-approved cessation therapies to replace tobacco. | Can cause nausea, dizziness and vomiting at moderate doses. |
| Enhances alertness and reaction time in fatigued individuals. | Lethal in high doses; about 60 mg can be fatal for an adult. |
| Has a well-understood receptor mechanism for research. | Harmful to adolescent brain development, affecting attention and impulse control. |
| Delivers effects rapidly, allowing precise dose control. | Constricts blood vessels, reducing circulation and increasing clot risk. |
| Available in multiple forms for varied user preferences. | Interacts with other drugs, altering their metabolism and effects. |
| Produces a calming effect after the initial stimulation. | Contributes to insulin resistance and metabolic disruption. |
| Helps some users manage appetite and weight. | Leads to tolerance, requiring higher doses to achieve the same effect. |
| Studied for potential neuroprotective properties. | Does not deliver the rewarding effect without frequent, repeated dosing. |
Similarities Between Tobacco and Nicotine
| Shared Aspect | How Tobacco and Nicotine Are Alike |
|---|---|
| Addictive Potential | Tobacco and nicotine both create strong physical dependence through brain receptor binding. |
| Primary Source | Tobacco and nicotine originate from the Nicotiana plant genus as their natural source. |
| Delivery Methods | Tobacco and nicotine use inhalation via smoking, vaping, or smokeless products. |
| Consumer Products | Tobacco and nicotine are sold commercially as cigarettes, patches, gums, and pouches. |
| Pharmacological Effects | Tobacco and nicotine stimulate dopamine release, producing temporary pleasure and alertness. |
| Health Warnings | Tobacco and nicotine products carry mandated health risk labels in most countries. |
| Regulatory Oversight | Tobacco and nicotine face strict government controls on advertising and sales. |
| Withdrawal Symptoms | Tobacco and nicotine cessation causes cravings, irritability, anxiety, and concentration issues. |
| Age Restrictions | Tobacco and nicotine sales are legally restricted to adults in most jurisdictions. |
| Metabolic Processing | Tobacco and nicotine are metabolized by the liver enzyme CYP2A6 into cotinine. |
| Cardiovascular Impact | Tobacco and nicotine increase heart rate and blood pressure shortly after use. |
| Usage Monitoring | Tobacco and nicotine exposure is measured through blood, urine, or saliva tests. |
| Harm Reduction Focus | Tobacco and nicotine have spawned industries aimed at reducing consumption harm. |
| Global Consumption | Tobacco and nicotine are used worldwide across diverse cultures and economies. |
| Taxation Targets | Tobacco and nicotine products often carry high sin taxes to discourage use. |
| Neurotransmitter Interaction | Tobacco and nicotine bind to nicotinic acetylcholine receptors in the brain. |
| Cessation Aids | Tobacco and nicotine dependence are treated with similar therapies and supports. |
| Environmental Presence | Tobacco and nicotine residues contaminate indoor air and surfaces through use. |
| Agricultural Origin | Tobacco and nicotine production begins with farming and leaf processing. |
| Consumer Demand | Tobacco and nicotine maintain steady markets despite known health risks. |
| Chemical Stability | Tobacco and nicotine degrade when exposed to light, heat, or air. |
| Dosage Control | Tobacco and nicotine products are designed to deliver controlled substance amounts. |
| Behavioral Rituals | Tobacco and nicotine use often involves repetitive hand-to-mouth actions. |
| Research Subject | Tobacco and nicotine are extensively studied in public health and medicine. |
| Trade Commodities | Tobacco and nicotine are globally traded commodities with established markets. |
| Packaging Standards | Tobacco and nicotine products follow strict labeling and child-resistant packaging rules. |
| Cross-Sensitivity | Tobacco and nicotine users often develop tolerance requiring higher doses. |
| Social Stigma | Tobacco and nicotine use faces increasing social disapproval and restrictions. |
| Economic Impact | Tobacco and nicotine industries generate significant revenue and employment globally. |
| Legacy Systems | Tobacco and nicotine have deeply entrenched production and distribution networks. |
Tobacco or Nicotine: Which Should You Choose?
Choose Nicotine if your goal is harm reduction, because nicotine itself is addictive but does not cause cancer. Choose Tobacco only if you accept the tar, carbon monoxide, and carcinogens from burning plant matter. The one variable that decides it is whether you are willing to inhale smoke.
When to Use Tobacco
Choose Tobacco when you require the full sensory ritual, flavor profile, or cultural tradition of smoking, chewing, or snuffing. It suits those who prioritize the authentic leaf experience over health outcomes, or who need the rapid 7-second brain delivery that only combusted plant matter provides. Budgets for premium cigars or pipe tobacco also apply here.
When to Use Nicotine
Choose Nicotine when your priority is quitting smoking, reducing toxicant exposure, or maintaining focus without combustion. It fits people using gum, patches, lozenges, or vaping to manage cravings, and those who need controlled, measured dosing. Choose it if you value lower long-term health risks compared to tobacco smoke, or if you must avoid secondhand smoke around others.
Common Misconceptions About Tobacco and Nicotine
| Common Myth | The Reality |
|---|---|
| Tobacco and nicotine are the exact same substance. | Tobacco is a plant leaf containing thousands of chemicals; nicotine is just one specific stimulant compound found within tobacco. |
| Nicotine causes cancer on its own. | Nicotine is not classified as a carcinogen; cancer risk from tobacco comes mainly from tar and other combustion byproducts, not nicotine itself. |
| All nicotine comes from tobacco plants. | Nicotine is also synthesized in labs or extracted from other nightshade plants like tomatoes and eggplants for use in gums and patches. |
| Chewing tobacco is safer because you don't inhale it. | Chewing tobacco still delivers nicotine and exposes users to carcinogens linked to oral, esophageal and pancreatic cancers. |
| Nicotine is only addictive when smoked as tobacco. | Nicotine is addictive regardless of delivery method; gums, lozenges and vapes all trigger the same dopamine reward pathway in your brain. |
| Organic tobacco contains no nicotine. | Organic tobacco refers to pesticide-free farming practices; the plant still naturally produces nicotine in its leaves at similar levels. |
| Nicotine replacement therapy is just swapping one addiction for another. | Nicotine replacement therapy uses controlled nicotine doses to ease withdrawal, but it lacks the harmful tar and carbon monoxide found in tobacco smoke. |
| Vaping delivers pure nicotine with no tobacco at all. | Most vaping liquids contain nicotine extracted from tobacco plants, though they skip the combustion process that creates tar and ash. |
| Tobacco is a chemical, while nicotine is natural. | Tobacco is a natural plant, and nicotine is the natural alkaloid it produces; both are botanical in origin, not synthetic lab creations. |
| Nicotine kills brain cells permanently. | Nicotine does not kill brain cells; it alters neurotransmitter activity, but research shows no evidence of permanent neuronal death from nicotine alone. |
| Light cigarettes contain less nicotine than regular ones. | Light cigarettes deliver similar nicotine levels as regular tobacco; smokers often inhale deeper to compensate, negating any reduction in intake. |
| Nicotine is a sedative that relaxes you. | Nicotine is a stimulant that raises heart rate and alertness; the relaxation smokers feel is relief from withdrawal symptoms between doses. |
| Tobacco leaves are the only part of the plant used for nicotine. | Nicotine is present throughout the tobacco plant, including stems and roots, but manufacturers primarily process cured leaves for commercial products. |
| Nicotine patches are more addictive than smoking tobacco. | Nicotine patches deliver a steady, low dose without the rapid spikes of smoked tobacco, making them less reinforcing and easier to taper off. |
| All tobacco products contain the same amount of nicotine. | Nicotine content varies wildly by product; a cigar can contain as much nicotine as multiple cigarettes, while some snus pouches have far less. |
| Nicotine is harmless when isolated from tobacco. | Nicotine still raises blood pressure and heart rate, and it harms adolescent brain development, so it is not harmless even without tobacco combustion. |
| Smokeless tobacco is a safe way to get nicotine. | Smokeless tobacco delivers nicotine but also contains 30-plus carcinogens, including nitrosamines, which cause mouth and pancreatic cancers. |
| Nicotine causes lung damage directly. | Lung damage from smoking tobacco comes from tar and irritant gases; nicotine itself primarily affects the cardiovascular and nervous systems, not lung tissue. |
| Tobacco is a modern invention created by corporations. | Tobacco has been cultivated and used by indigenous Americas for thousands of years, long before modern tobacco companies ever existed. |
| Nicotine is the same as caffeine in terms of addiction potential. | Nicotine is significantly more addictive than caffeine; it produces faster tolerance and stronger withdrawal symptoms in most users. |
| Heated tobacco products contain no nicotine. | Heated tobacco products still contain nicotine from real tobacco leaves; they just heat rather than burn the plant to reduce some toxins. |
| Nicotine is only dangerous for the person using it. | Nicotine constricts blood vessels in pregnant women, reducing fetal oxygen; secondhand exposure from tobacco smoke also harms bystanders. |
| One cigar is safer than one cigarette because you don't inhale. | Cigars contain far more tobacco leaf and nicotine than cigarettes, and mouth-holding still absorbs nicotine through oral membranes. |
| Nicotine makes you lose weight permanently. | Nicotine does suppress appetite short-term, but weight gain often returns after quitting tobacco, making the effect temporary and not sustainable. |
| Tobacco-free nicotine is completely risk-free. | Tobacco-free nicotine still carries cardiovascular risks and addiction potential; it lacks tobacco toxins but is not a zero-risk substance. |
| Nicotine is a pesticide that proves it is toxic. | Nicotine is a natural insecticide in tobacco plants, but its toxicity to insects does not equate to the same lethal dose for humans. |
| All nicotine is extracted from tobacco for commercial use. | Some nicotine in modern products is synthetic or derived from other plants, but most commercial nicotine still comes from tobacco leaf extraction. |
| Quitting tobacco means quitting nicotine entirely. | Quitting tobacco can involve continued nicotine use via patches or gum, which helps break the smoking habit without the harmful smoke. |
| Nicotine is a gateway drug that leads to harder substances. | Nicotine does not chemically cause other drug use; correlation with gateway effects stems from social and behavioral factors, not the compound itself. |
| Tobacco and nicotine are both legal everywhere for adults. | Legal status varies globally; nicotine products face age restrictions in most nations, and some countries ban tobacco sales or nicotine vaping entirely. |
Conclusion
Difference Between Tobacco and Nicotine is that tobacco is a plant containing thousands of chemicals, while nicotine is just one addictive compound found within it. Choose tobacco-free nicotine products to avoid the harmful toxins. Choose to avoid both entirely for the safest health outcome.
FAQs on Difference Between Tobacco and Nicotine
- What is the difference between tobacco and nicotine?
- Tobacco is a leafy plant, while nicotine is a chemical compound naturally found within that plant's leaves.
- Is nicotine the same thing as tobacco?
- No, nicotine is not the same as tobacco because nicotine is just one active ingredient, whereas tobacco contains thousands of other chemicals.
- Which is more addictive, tobacco or nicotine?
- Nicotine is the primary addictive substance, so pure nicotine drives dependence, but tobacco's other compounds also influence the overall addiction profile.
- Is nicotine safer than tobacco?
- Nicotine itself is generally less harmful than tobacco, because tobacco smoke delivers toxic tar and carcinogens that pure nicotine products do not contain.
- Does all tobacco contain nicotine?
- Yes, all tobacco plants naturally contain nicotine, though the exact concentration varies significantly depending on the specific plant variety and growing conditions.
- Can you have nicotine without tobacco?
- Yes, you can have nicotine without tobacco, as nicotine replacement therapies and e-liquids use synthetic or extracted nicotine that is free from plant material.
- What is a common beginner mistake when comparing tobacco and nicotine? A common beginner mistake is assuming nicotine causes cancer, when in fact it is the harmful combustion byproducts of tobacco smoke that are the primary carcinogens. Is it better to use nicotine gum instead of smoking tobacco?
- Yes, nicotine gum is better than smoking tobacco because it delivers nicotine without the toxic smoke, significantly reducing the risk of lung cancer and respiratory disease.
- Can I switch from tobacco products to pure nicotine products?
- Yes, you can switch from tobacco products to pure nicotine products, a strategy known as harm reduction that eliminates exposure to deadly combustion toxins.
- How much does nicotine cost compared to tobacco?
- Nicotine replacement products often cost more upfront than loose tobacco, but they can be cheaper over time because they are used in measured doses rather than smoked continuously.
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